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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:52 UTC
Update Date2022-03-07 02:52:04 UTC
HMDB IDHMDB0015655
Secondary Accession Numbers
  • HMDB15655
Metabolite Identification
Common NameMethyltestosterone
DescriptionMethyltestosterone, also known as android or testred, belongs to the class of organic compounds known as androgens and derivatives. These are 3-hydroxylated C19 steroid hormones. They are known to favor the development of masculine characteristics. They also show profound effects on scalp and body hair in humans. Thus, methyltestosterone is considered to be a steroid lipid molecule. Methyltestosterone is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Methyltestosterone is a potentially toxic compound.
Structure
Data?1582753320
Synonyms
ValueSource
17(alpha)-Methyl-Delta(4)-androsten-17(beta)-ol-3-oneChEBI
17-beta-Hydroxy-17-methylandrost-4-en-3-oneChEBI
17-MethyltestosteroneChEBI
17alpha-Methyl-3-oxo-4-androsten-17beta-olChEBI
17alpha-Methyl-Delta(4)-androsten-17beta-ol-3-oneChEBI
17alpha-MethyltestosteroneChEBI
17beta-Hydroxy-17-methylandrost-4-en-3-oneChEBI
4-Androstene-17alpha-methyl-17beta-ol-3-oneChEBI
AndroidChEBI
MethyltestosteronumChEBI
MetiltestosteronaChEBI
NSC-9701ChEBI
TestredChEBI
VirilonChEBI
17(a)-Methyl-delta(4)-androsten-17(b)-ol-3-oneGenerator
17(Α)-methyl-δ(4)-androsten-17(β)-ol-3-oneGenerator
17-b-Hydroxy-17-methylandrost-4-en-3-oneGenerator
17-Β-hydroxy-17-methylandrost-4-en-3-oneGenerator
17a-Methyl-3-oxo-4-androsten-17b-olGenerator
17Α-methyl-3-oxo-4-androsten-17β-olGenerator
17a-Methyl-delta(4)-androsten-17b-ol-3-oneGenerator
17Α-methyl-δ(4)-androsten-17β-ol-3-oneGenerator
17a-MethyltestosteroneGenerator
17Α-methyltestosteroneGenerator
17b-Hydroxy-17-methylandrost-4-en-3-oneGenerator
17Β-hydroxy-17-methylandrost-4-en-3-oneGenerator
4-Androstene-17a-methyl-17b-ol-3-oneGenerator
4-Androstene-17α-methyl-17β-ol-3-oneGenerator
17(a)-Methyl-δ(4)-androsten-17(b)-ol-3-oneHMDB
17a-Methyl-δ(4)-androsten-17b-ol-3-oneHMDB
17alpha-Methyl-delta-androsten-17beta-ol-3-oneHMDB
17 EpimethyltestosteroneHMDB
17 beta MethyltestosteroneHMDB
17alpha MethyltestosteroneHMDB
MesteronHMDB
17 beta-MethyltestosteroneHMDB
17-EpimethyltestosteroneHMDB
17beta Hydroxy 17 methyl 4 androsten 3 oneHMDB
17beta MethyltestosteroneHMDB
17beta-Hydroxy-17-methyl-4-androsten-3-oneHMDB
Android-25HMDB
Global pharmaceutical brand OF methyltestosteroneHMDB
ICN brand 1 OF methyltestosteroneHMDB
ICN brand 2 OF methyltestosteroneHMDB
17 alpha MethyltestosteroneHMDB
17-alpha-MethyltestosteroneHMDB
17alpha-Methyl-testosteroneHMDB
Android 25HMDB
Android 5HMDB
Android-5HMDB
MetandrenHMDB
Star brand OF methyltestosteroneHMDB
17 beta Hydroxy 17 methyl 4 androsten 3 oneHMDB
17 beta-Hydroxy-17-methyl-4-androsten-3-oneHMDB
17alpha Methyl testosteroneHMDB
17beta-MethyltestosteroneHMDB
Android 10HMDB
Android-10HMDB
MesteroneHMDB
MethitestHMDB
OretonHMDB
Schering brand OF methyltestosteroneHMDB
TestovironHMDB
MethyltestosteroneMeSH
Android (methyltestoterone)MeSH
Chemical FormulaC20H30O2
Average Molecular Weight302.451
Monoisotopic Molecular Weight302.224580204
IUPAC Name(1S,2R,10R,11S,14S,15S)-14-hydroxy-2,14,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
Traditional Name(1S,2R,10R,11S,14S,15S)-14-hydroxy-2,14,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
CAS Registry Number58-18-4
SMILES
[H][C@@]12CC[C@](C)(O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
InChI Identifier
InChI=1S/C20H30O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h12,15-17,22H,4-11H2,1-3H3/t15-,16+,17+,18+,19+,20+/m1/s1
InChI KeyGCKMFJBGXUYNAG-HLXURNFRSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as androgens and derivatives. These are 3-hydroxylated C19 steroid hormones. They are known to favor the development of masculine characteristics. They also show profound effects on scalp and body hair in humans.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassAndrostane steroids
Direct ParentAndrogens and derivatives
Alternative Parents
Substituents
  • Androgen-skeleton
  • 3-oxo-delta-4-steroid
  • 3-oxosteroid
  • Hydroxysteroid
  • Oxosteroid
  • 17-hydroxysteroid
  • Delta-4-steroid
  • Cyclohexenone
  • Tertiary alcohol
  • Cyclic alcohol
  • Ketone
  • Cyclic ketone
  • Organooxygen compound
  • Alcohol
  • Carbonyl group
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.014 g/LNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+CBM176.030932474
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.014 g/LALOGPS
logP3.61ALOGPS
logP3.65ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)19.09ChemAxon
pKa (Strongest Basic)-0.53ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area37.3 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity89.07 m³·mol⁻¹ChemAxon
Polarizability35.85 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+174.09331661259
DarkChem[M-H]-171.05431661259
DeepCCS[M-2H]-206.03830932474
DeepCCS[M+Na]+180.09230932474
AllCCS[M+H]+177.332859911
AllCCS[M+H-H2O]+174.232859911
AllCCS[M+NH4]+180.132859911
AllCCS[M+Na]+180.932859911
AllCCS[M-H]-183.532859911
AllCCS[M+Na-2H]-183.832859911
AllCCS[M+HCOO]-184.232859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
Methyltestosterone[H][C@@]12CC[C@](C)(O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C3622.6Standard polar33892256
Methyltestosterone[H][C@@]12CC[C@](C)(O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C2594.1Standard non polar33892256
Methyltestosterone[H][C@@]12CC[C@](C)(O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C2745.5Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Methyltestosterone,1TMS,isomer #1C[C@]1(O[Si](C)(C)C)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C2802.5Semi standard non polar33892256
Methyltestosterone,1TMS,isomer #2C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C)=CC[C@]4(C)[C@H]3CC[C@@]21C2658.8Semi standard non polar33892256
Methyltestosterone,2TMS,isomer #1C[C@]1(O[Si](C)(C)C)CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C)=CC[C@]4(C)[C@H]3CC[C@@]21C2726.5Semi standard non polar33892256
Methyltestosterone,2TMS,isomer #1C[C@]1(O[Si](C)(C)C)CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C)=CC[C@]4(C)[C@H]3CC[C@@]21C2747.1Standard non polar33892256
Methyltestosterone,2TMS,isomer #1C[C@]1(O[Si](C)(C)C)CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C)=CC[C@]4(C)[C@H]3CC[C@@]21C2933.1Standard polar33892256
Methyltestosterone,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)O[C@@]1(C)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C3055.7Semi standard non polar33892256
Methyltestosterone,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CC[C@](C)(O)[C@@]3(C)CC[C@@H]122956.1Semi standard non polar33892256
Methyltestosterone,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CC[C@](C)(O[Si](C)(C)C(C)(C)C)[C@@]3(C)CC[C@@H]123256.4Semi standard non polar33892256
Methyltestosterone,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CC[C@](C)(O[Si](C)(C)C(C)(C)C)[C@@]3(C)CC[C@@H]123220.5Standard non polar33892256
Methyltestosterone,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CC[C@](C)(O[Si](C)(C)C(C)(C)C)[C@@]3(C)CC[C@@H]123177.1Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Methyltestosterone GC-MS (Non-derivatized) - 70eV, Positivesplash10-00dr-0290000000-371930adb441ed4569542017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Methyltestosterone GC-MS (1 TMS) - 70eV, Positivesplash10-0aba-1219000000-f0c8c14754130edea3b12017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Methyltestosterone GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
MSMass Spectrum (Electron Ionization)splash10-006x-7921000000-0e8f2747a2f3c81660482014-09-20Not AvailableView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone , positive-QTOFsplash10-0udi-1329000000-c8db8c2a5d8403c476e12017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone 45V, Positive-QTOFsplash10-052b-6910000000-9318ec38a89b29c5640a2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone 30V, Positive-QTOFsplash10-0udj-5869000000-d793d0f4b0e7a48b07f62021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone 30V, Positive-QTOFsplash10-0f9i-0951000000-9748785b49ecb149e24a2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone 20V, Positive-QTOFsplash10-0udi-0139000000-8aa4cb730b0ff1f71ea42021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone 35V, Positive-QTOFsplash10-0k92-4933000000-7acf74ca59be288f26142021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone 10V, Positive-QTOFsplash10-0udi-0009000000-ae79c4e9732d83ed38d92021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone 50V, Positive-QTOFsplash10-05gi-0900000000-d1cbdda02301f6a942882021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone 40V, Positive-QTOFsplash10-00ea-0910000000-3f3f55e272ef7299acdf2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone 90V, Positive-QTOFsplash10-054k-9400000000-bf00a69bc23c369a23312021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone 15V, Positive-QTOFsplash10-0udi-0009000000-d366eb35472b9a72d3ba2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone 75V, Positive-QTOFsplash10-052b-9600000000-ff447f9aa855eb5ec7012021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone 60V, Positive-QTOFsplash10-052b-8900000000-f4aa99526d10876e16d42021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone 50V, Positive-QTOFsplash10-05gi-0900000000-988e08204d56c840af722021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone 40V, Positive-QTOFsplash10-00ea-0910000000-4231a8d617491b2005622021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Methyltestosterone 30V, Positive-QTOFsplash10-0f9i-0951000000-ef720a8b9da17a0ec5a32021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Methyltestosterone 10V, Positive-QTOFsplash10-0f79-0195000000-6ddd9c839c0b3b88c6912016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Methyltestosterone 20V, Positive-QTOFsplash10-0f79-0391000000-2fe2bafacddeeeb1f5f52016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Methyltestosterone 40V, Positive-QTOFsplash10-0gbc-3890000000-9798d48acbfa04cc8bf02016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Methyltestosterone 10V, Negative-QTOFsplash10-0udi-0029000000-5462129b9677fa78ae8a2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Methyltestosterone 20V, Negative-QTOFsplash10-0udi-0059000000-989aea076743d8116d132016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Methyltestosterone 40V, Negative-QTOFsplash10-052u-0190000000-c80d428af7a5f339800c2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Methyltestosterone 10V, Positive-QTOFsplash10-0udr-0169000000-ad3e6ae0c33f0dc6369e2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Methyltestosterone 20V, Positive-QTOFsplash10-000j-0941000000-ec696476679a2f83bba52021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Methyltestosterone 40V, Positive-QTOFsplash10-01tl-2910000000-96766b244c1b4bb1e6a82021-10-11Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB06710 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB06710 details
Abnormal Concentrations
Not Available
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood0.000 uMAdult (>18 years old)BothNormalPredicted based on drug qualities
Blood0.000 umol/mmol creatinineAdult (>18 years old)BothNormalPredicted based on drug qualities
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB06710
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID5788
KEGG Compound IDC07198
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkMethyltestosterone
METLIN IDNot Available
PubChem Compound6010
PDB IDNot Available
ChEBI ID27436
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Simons K, Toomre D: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9. [PubMed:11413487 ]
  2. Watson AD: Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res. 2006 Oct;47(10):2101-11. Epub 2006 Aug 10. [PubMed:16902246 ]
  3. Sethi JK, Vidal-Puig AJ: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62. Epub 2007 Mar 20. [PubMed:17374880 ]
  4. Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621. [PubMed:20044567 ]
  5. Gunstone, Frank D., John L. Harwood, and Albert J. Dijkstra (2007). The lipid handbook with CD-ROM. CRC Press.

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular weight:
56277.81
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Gene Name:
CYP19A1
Uniprot ID:
P11511
Molecular weight:
57882.48
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in DNA binding
Specific function:
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3
Gene Name:
AR
Uniprot ID:
P10275
Molecular weight:
98987.9
References
  1. Small EJ, Ryan CJ: The case for secondary hormonal therapies in the chemotherapy age. J Urol. 2006 Dec;176(6 Pt 2):S66-71. [PubMed:17084172 ]
  2. Omwancha J, Brown TR: Selective androgen receptor modulators: in pursuit of tissue-selective androgens. Curr Opin Investig Drugs. 2006 Oct;7(10):873-81. [PubMed:17086931 ]
  3. Petraki CD, Sfikas CP: Histopathological changes induced by therapies in the benign prostate and prostate adenocarcinoma. Histol Histopathol. 2007 Jan;22(1):107-18. doi: 10.14670/HH-22.107. [PubMed:17128417 ]
  4. Maudsley S, Davidson L, Pawson AJ, Freestone SH, Lopez de Maturana R, Thomson AA, Millar RP: Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5. Neuroendocrinology. 2006;84(5):285-300. Epub 2007 Jan 4. [PubMed:17202804 ]
  5. Lapauw B, Goemaere S, Crabbe P, Kaufman JM, Ruige JB: Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men? Eur J Endocrinol. 2007 Mar;156(3):395-401. [PubMed:17322500 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Transporters

General function:
Involved in transporter activity
Specific function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular weight:
74144.1
References
  1. Lu R, Kanai N, Bao Y, Wolkoff AW, Schuster VL: Regulation of renal oatp mRNA expression by testosterone. Am J Physiol. 1996 Feb;270(2 Pt 2):F332-7. [PubMed:8779895 ]
  2. Kanai N, Lu R, Bao Y, Wolkoff AW, Vore M, Schuster VL: Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am J Physiol. 1996 Feb;270(2 Pt 2):F326-31. [PubMed:8779894 ]
  3. Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. [PubMed:8786566 ]